These insects are generally larger in temperate areas than in the tropics. An official website of the United States government. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. By using our site, you acknowledge that you have read and understand our Privacy Policy PCR was run on all samples with primers targeting BNT162b2, as shown in Figure 1 and Table 1. Huang X, Kong N, Zhang X, Cao Y, Langer R, Tao W. Nat Med. We show that the vaccine enters liver cells as early as six hours after the vaccine has been administered. badbunny. Salesforce Reportedly Pays Matthew McConaughey $10 Million A Year Despite Massive Employee Layoffs Last Month, The Boring Company CEO Is Set To be The Next CEO Of Twitter, OH city violates state pre-emption, carjackings explode in NOLA, Canada hates US gun laws. Khehra N, Padda I, Jaferi U, Atwal H, Narain S, Parmar MS. AAPS PharmSciTech. The whole process occurred rapidly within six hours. These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells DNA in the genome - and if so, if it has any consequences, Rasmussen says in the article. As such, even a rather long stretch of shared amino acids is not going to make two proteins automatically recognizable by the same antibodies because one or the other of the similar portions may be hidden within the 3D shape. MR: These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells' DNA in the genomeand if so, if it has any consequences. The vaccine was administered in different amounts and for different lengths of time. Telephone: +46 (0)46 222 00 00 (switchboard) For these reasons, while the changes related to LINE-1 are interesting, we cant be sure the effects would be the same in a non-cancerous cell line. WebPfizer Vaccine Becomes DNA in Liver Cells. Click here to sign in with The authors said that they chose to study liver cells as Pfizer had reported that about 18% of the vaccine accumulated in the liver in 30 minutes after mice were injected. The research was conducted at Lund University. In adifferent study, the spike proteins made in the body after receiving a Pfizer COVID-19 shot have been found on tiny membrane vesicles called exosomesthat mediate cell-to-cell communication by transferring genetic materials to other cellsfor at least four months after the second vaccine dose. Our monetization model empowers Citizen Journalists to report the news in local and national markets. It only presents the body with the instructions to build immunity.. These vaccines deliver genetic material that instructs cells to begin making spike proteins found on the surface of SARS-CoV-2 that causes COVID-19 to produce an immune response. The results have been widely discussed across social mediabut the results have in many cases been misinterpreted. The authors of a Swedish study said their study could not be used to draw conclusions with human DNA as they used cell lines in a laboratory petri dish for their work. Whether our results are true for other cell types in humans, or if they are specific to mRNA vaccines, are among many questions for further research. YDM: One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. Rasmussen explained in the article that there was no reason to change the decision to receive a vaccine based on the study. In the cell line in a petri dish, you dont have those checks in place.. If you take just one thing away from this series, we hope you will have come to realize that science does not easily fit into a sound bite and, most often, it is not an either-or proposition, so if something sounds too simple, you probably need to ask more questions. This is part of APs effort to address widely shared misinformation, including work with outside companies and organizations to add factual context to misleading content that is circulating online. The experiment was conducted in a petri dish and aimed to answer the question of whether the mRNA in the vaccine could be converted to DNA. First, all proteins are made of building blocks known as amino acids. Whether the findings of the study will occur in living organisms or if the DNA converted from the vaccines mRNA will integrate with the cells genome is unknown. Does the Pfizer-BioNTech mRNA vaccine get converted to DNA or not? As we discussed in, The quantity of a genetic tool called LINE-1, The presence of DNA sequences similar to the vaccine RNA in the nuclei of these cells, Perhaps most importantly, this experiment was done on cells being grown in a lab. hasty generalization and appeal to ignorance. MR: We understood that the study would attract attention, but we think it is self-evident that this type of research should be pursued. YDM: This study does not investigate whether the Pfizer vaccine alters our genome. doi: 10.1038/s41586-020-2639-4. Contact us Huh7 cells were treated, Immunohistochemistry of Huh7 cells treated, Immunohistochemistry of Huh7 cells treated with BNT162b2 on LINE-1 protein distribution. 2021 Dec 22;9(3):e0116221. 2023 Jan 19. They are not sure if it gets integrated in our DNA or not. In part I, we focused on the big picture. MR: There is no reason for anyone to change their decision to take the vaccine based on this study. Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. This also explains the choice of vaccine concentrations in our study, something we specifically address in the paper, which are 0.5-2% of the injection site concentration. Neither your address nor the recipient's address will be used for any other purpose. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. Our COVID-19 vaccine does not alter the DNA sequence of a human cell, a Pfizer spokesperson told The Epoch Times in an email. (in-vitro swedish study) https://lnkd.in/df6hkugy The two that have made the news recently are the Pfizer vaccine and the Moderna vaccine. 41.1M. doi: 10.1503/cmaj.211881. Our publication is the first in vitro study on the conversion of mRNA vaccine into DNA, inside cells of human origin. In the case of Covid shots, the vaccines from Moderna and Pfizer /BioNTech introduce a single spike protein. is the set of instructions to build and sustain a human being. This is important for two reasons; both of which were acknowledged by the authors. No information in this video should ever be considered as a substitute for advice from a healthcare professional.\r\rURL list from Friday, Feb. 25 2022\r\rCIMB | Free Full-Text | Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line | HTML\rhttps://www.mdpi.com/1467-3045/44/3/73/htm\r\rFrontiers | Identification of Characteristic Genomic Markers in Human Hepatoma HuH-7 and Huh7.5.1-8 Cell Lines | Genetics\rhttps://www.frontiersin.org/articles/10.3389/fgene.2020.546106/full#:~:text=HuH%2D7%20(hereafter%20Huh7),experimental%20substitute%20for%20primary%20hepatocytes.\r\rURL list from Monday, Feb. 28 2022\r\rCIMB | Free Full-Text | Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line | HTML\rhttps://www.mdpi.com/1467-3045/44/3/73/htm\r\rLINE-1 protein localization and functional dynamics during the cell cycle | eLife\rhttps://elifesciences.org/articles/30058\r\rTime evolution of PEG-shedding and serum protein coronation determines the cell uptake kinetics and delivery of lipid nanoparticle formulated mRNA | bioRxiv\rhttps://www.biorxiv.org/content/10.1101/2021.08.20.457104v1\r\rReverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues - PubMed\rhttps://pubmed.ncbi.nlm.nih.gov/33958444/\r\rNo evidence of SARS-CoV-2 reverse transcription and integration as the origin of chimeric transcripts in patient tissues - PMC\rhttps://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8379926/\r\rOverview of Reverse Transcription - Retroviruses - NCBI Bookshelf\rhttps://www.ncbi.nlm.nih.gov/books/NBK19424/\r\rNuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus | Nature Microbiology\rhttps://www.nature.com/articles/s41564-020-0735-8\r\rChimeric RNA - Wikipedia\rhttps://en.wikipedia.org/wiki/Chimeric_RNA\r\rBenchtop Automation for Immunohistochemistry (IHC), ISH \u0026 Special Stains (SS) - NanoMtrx 300 - YouTube\rhttps://www.youtube.com/watch?v=3IRl0kbR9-o\u0026ab_channel=BioGenexLaboratories\r\rSchrdinger's cat - Wikipedia\rhttps://en.wikipedia.org/wiki/Schr%C3%B6dinger%27s_cat In interpreting this data, some people chose to focus only on the similar values in the first few days of the curve and use that to suggest that vaccinated people were equally likely to spread the virus compared with unvaccinated people. The content is provided for information purposes only. Skip to main content. The Study Has Received A Lot of Media Attention, What Are Your Thoughts on That? Dr. Peter McCullough, an internist, cardiologist and epidemiologist who is one of the leading critics of the COVID vaccines, said the findings have enormous implications of permanent chromosomal change that could drive a whole new genre of chronic disease., The CDC assures Americans that the mRNA and the spike protein it produces in COVID-19 vaccines to create an immune response dont last long in the body. On its website, the agency states: Our cells break down mRNA and get rid of it within a few days after vaccination. So, one may quickly realize that with 20 building blocks and tens or hundreds of thousands of proteins, small (sometimes even large) stretches of overlap are likely to occur. In thisstudywe present evidence that COVID-19 mRNA vaccine BNT162b2 is able to enter the human liver cell line Huh7 in vitro, the researchers wrote in the study, published inCurrent Issues of Molecular Biology. Sudden deaths of Canadian Giving to Lund Still, the Swedish study only demonstrated that RNA had converted to DNA under the particular conditions created in the lab, not in a human body. or, by Lund University. WebFew vaccines have been launched for this purpose recently with different side effects. The data represent RNA levels not viral particles, so while the patient samples required equal cycles of PCR to detect RNA, we cant speak to a persons contagiousness because this study does not tell us how much whole virus was present in their nasal passages. 5. Let's review.\r\rIf you like this content and want more, I am doing a special lifetime membership offer. Researchers found that the entire process of the Pfizer COVID vaccine becoming DNA in liver cells took about six hours. The text in one post reads: BOMBSHELL: Biological Study PROVES Pfizer mRNA Vaccine Permanently Alters Human DNA. According to the study, once the mRNA vaccine enters the human liver cells, it triggers the cell's DNA inside the nucleus to produce more of the LINE-1 gene expression to make mRNA. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. Drugs and Lactation Database (LactMed) [Internet]. doi: 10.1128/Spectrum.01162-21. some scientists have suggested that integration of SARS-CoV-2 genetic material into human cells could be why some people still test positive by PCR well after they have recovered from their infection. WebThe interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. "LINE-1 can convert RNA to DNA and has been shown to be found in tissues, including stem cells, in the human body. Press Office Another aspect of protein chemistry is also important. Experts say that such interpretations mischaracterize the work and come to inaccurate conclusions. Pfizer Vaccine Becomes DNA in Liver Cells. If you dont have time (or interest) in reviewing the primary source of the information, it is often best to let the information die in your feed or your inbox. A new Swedish study published in MDPIfound that the Pfizer vaccine goes into liver cells and converts to DNA, challenging claims so far that the mRNA COVID-19 vaccines do not change or interact with your DNA in any way. The paper does not provide such evidence. The American Association of Liver Disease has recently published consensus statements for COVID-19 vaccination in subjects with chronic liver disease (CLD). On the figure, the two lines (comparing vaccinated and unvaccinated patient data) are almost in the same place for the first four or five days of illness, but then they separate, and the vaccinated group more quickly requires higher numbers of PCR cycles to detect viral RNA, meaning there was less virus in those samples. However, the researchers at Lund University in Malm, Sweden, found that the mRNA vaccine enters human liver cells and triggers the cells DNA in the nucleus to increase the production of the LINE-1 gene expression to make mRNA. Epub 2022 Feb 3. The claim was also debunked by fact checker Health Feedback, which delved into the scientific claims in more detail (here). You should not use it to replace any relationship with a physician or other qualified healthcare professional. The CDC says that the COVID-19 vaccines do not change or interact with your DNA in any way, claiming that all of the ingredients in both mRNA and viral vector COVID-19 vaccines (administered in the United States) are discarded from the body once antibodies are produced. The authors said that they chose to study liver cells as Pfizer had reported that about 18% of the vaccine accumulated in the liver in 30 minutes after mice were The study, conducted by researchers at Lund University in Sweden and published in a peer-reviewed journal, investigated the effect of Pfizers mRNA COVID-19 vaccine on a human cell line that was derived from liver cancer tissue. -, Polack F.P., Thomas S.J., Kitchin N., Absalon J., Gurtman A., Lockhart S., Perez J.L., Perez Marc G., Moreira E.D., Zerbini C., et al. The content provided in this video is for informational and educational purposes only.\rPlease consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. It is known from animal studies that it is also expressed early in embryonic development", explains Yang de Marinis. Every cell within our human body is undergoing regular checks, and when you get an abnormal cell, that abnormal cell is then broken down and deleted, Strain said. The more virus in a sample, the fewer cycles it would take to detect RNA. During the study, the researchers were able to detect DNA that had been converted from the vaccines mRNA in the lab-modified cell. Unauthorized use of these marks is strictly prohibited. In order to create these cell lines, the genetic make-up of the cells has to be fiddled with to make them immortal and keep them alive in the petri dish, Dr. David Strain, a senior clinical lecturer at Englands University of Exeter Medical School, wrote in an email to the AP. A clip being shared online in recent days shows three doctors, who have spread misinformation about the vaccines in the past, discussing the Swedish study and falsely claiming it demonstrates that the Pfizer vaccine reverse transcribes and installs DNA into the human genome, leading to harmful effects. YDM: One of the limitations of our study is that we don't know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. At the heart of the misconceptions about this paper is figure 1, which shows viral shedding among vaccinated (green) and unvaccinated (red) individuals. , conducted by researchers at Lund University in Sweden and published in a peer-reviewed journal, investigated the effect of Pfizers mRNA COVID-19 vaccine on a human cell line that was derived from liver cancer tissue. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. Of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in Vitro in human liver cell line after the has. Show that pfizer vaccine becomes dna in liver vaccine has been administered address nor the recipient 's address be. I, Jaferi U, Atwal H, Narain S, Parmar AAPS... And want more, I am doing a special lifetime membership offer 5 Notably, mutations in the tumor-suppressor. The tropics researchers found that the vaccine enters liver cells as early as hours! 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